Sciencell Human Primary Annulus Fibrosus Cells

ScienCell’s Human Primary Cells

ScienCell’s human primary cells are isolated from normal human tissue. They are cryopreserved immediately after purification and delivered frozen. All cells are rigorously tested to meet our high standard and specifications. ScienCell’s primary cells should be cultured in a 37°C, 5% CO2 incubator to maintain the optimal pH of the medium.

Sciencell Human Primary Annulus Fibrosus Cells

Degeneration of the intervertebral disk is a major pathological process implicated in low back pain. The causes of low back pain include genetics, environmental factors, and psychosocial factors. The anulus fibrosus makes up the peripheral portion of the disk structure, and is composed of fibrocartilage and type I and II collagen. Cells of the intervertebral disc are influenced by both biophysical and mechanical factors in their local environment. The anulus fibrosus cells can be stimulated by interleukin 1 beta to produce factors implicated in local degradative and inflammatory processes. Although mechanical stress is an important modulator of degeneration, the underlying molecular mechanism remains unclear. Human annulus fibrosus cells provide an in vitro model for the study of cellular and molecular events involved in disc degeneration, tissue engineering and cell therapy for spinal disc disorders.