Sciencell Human Primary Osteoblasts Cell

ScienCell’s Human Primary Cells

ScienCell’s human primary cells are isolated from normal human tissue. They are cryopreserved immediately after purification and delivered frozen. All cells are rigorously tested to meet our high standard and specifications. ScienCell’s primary cells should be cultured in a 37°C, 5% CO2 incubator to maintain the optimal pH of the medium

Sciencell Human Primary Osteoblasts Cell

Bone is a dynamic tissue, being continuously remodeled by the coordinated actions of osteoclasts and osteoblasts. Osteoblasts, the bone-forming cells, are derived originally from pluripotent mesenchymal stem cells. They synthesize and secrete organic extracellular matrix, osteoid, which is composed primarily of type I collagen. Osteoid is calcified by osteoblasts and during this process the cells become encased in lacunae within the calcified material and become osteocytes. Osteoblasts express protease-activated receptor-1 and vascular endothelial cell growth factor. Studies show that leukemia inhibitory factor can bind to the osteoblast cell surface and induce bone formation both in vitro and in vivo. The balance between osteoblast recruitment, proliferation, differentiation and apoptosis in sutures between cranial bones is essential for calvarial bone formation.

Recommended Medium

Osteoblast Medium (#4601)